Risk of Spontaneous Bacterial Peritonitis Associated With Gastric Acid Suppression

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Risk of Spontaneous Bacterial Peritonitis Associated With Gastric Acid Suppression

The primary objective of this study was to determine the association between the use of gastric acid suppressants (GAS) and the risk of developing spontaneous bacterial peritonitis (SBP) in patients with advanced liver cirrhosis (LC). A case-control study nested within a cohort of 480,000 representatives of Taiwan National Health Insurance beneficiaries was carried out. A case was matched with ...

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Spontaneous bacterial peritonitis.

Spontaneous bacterial peritonitis (SBP) is a common, serious complication in patients with cirrhosis and ascites. It is a bacterial infection of ascitic fluid in the absence of an adjacent, surgically amenable infection source. Since its description in 1964 (1) numerous studies, guidelines, and both national and international consensus conferences have brought significant advancement to the dia...

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["Spontaneous" bacterial peritonitis].

Since its initial description in 1964, research has transformed spontaneous bacterial peritonitis (SBP) from a feared disease (with reported mortality of 90%) to a treatable complication of decompensated cirrhosis, albeit with steady prevalence and a high recurrence rate. Bacterial translocation, the key mechanism in the pathogenesis of SBP, is only possible because of the concurrent failure of...

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Spontaneous Bacterial Peritonitis

at 20% to 40%.4,5 If the patient survives that hospitalization, one-year and two-year mortality rates for those with SBP are approximately 70% and 80%, respectively.3,6–10 Further adding to the inherent morbidity of SBP is its proclivity for recurrence. After an episode of SBP has been successfully cleared with antibiotic therapy, recurrence rates range from 40% to 70% within the first year.3,6...

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Spontaneous bacterial peritonitis.

Spontaneous bacterial peritonitis (SBP) is a bacterial infection of ascitic fluid in patients with decompensated cirrhosis. The modifier 'spontaneous' distinguishes this from surgical peritonitis. The infecting organisms are usually enteric gram-negatives which have translocated from the bowel. Symptoms of infection occur in most patients with SBP, including fever, abdominal pain, mental status...

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ژورنال

عنوان ژورنال: Medicine

سال: 2015

ISSN: 0025-7974

DOI: 10.1097/md.0000000000000944